Several Types of Pain Relievers 

    Paracetamol. This type of pain reliever is easiest to get without a doctor's prescription. Paracetamol does not have anti-inflammatory properties and can be used for headaches/migraines, high-grade injuries, chronic low back pain. If used excessively it can cause liver damage.
    Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). There are several types that are classified as NSAIDs, including aspirin, ibuprofen, meloxicam, diclofenac and ketorolac. Some of these medicines can be purchased freely and some must be purchased with a doctor's prescription. Ibuprofen and diclofenac can cause serious side effects such as stomach ulcers and bleeding. Pain relievers also increase the risk of cardiovascular disease, especially when taken over longer periods of time and in high doses 
    Opioids and Opiates. This type of drug includes codeine, tramadol, hydrocodone, morphine, hydromorphone and fentanyl which require a doctor's prescription. The types of pain treated by this drug are severe injury or trauma, major surgery and cancer pain. It is possible that these drugs are capable of causing addiction so the lowest effective dose should be used for the shortest possible duration 
    Anticonvulsants, antidepressants and local anesthetics. Pain that can be treated with this type of anti-pain is pain due to nerve damage or disorders, neuropathy, phantom leg pain, fibromyalgia, chronic low back pain and cancer pain. Examples of anti-pain drugs are gabapentin, pregabalin, duloxetine and lidocaine.

How does the body respond to becoming resistant to drugs that are often taken? 

When one part of the body experiences pain or pain, the brain will produce chemicals that cause pain and then anti-pain medication will work to stop the brain from producing these substances. However, when someone takes these drugs too often in inappropriate doses, the body will adapt and be unable to stop the chemicals produced by the brain. When that happens, you need more doses so that the body becomes sensitive again to the presence of painkillers entering the body.

Therefore, it is important to know and apply that each person has a different tolerance and response to drugs. If you have questions or are still unsure about the appropriate use of pain relievers, please consult a doctor to get the right information and treatment according to your condition. Healthy greetings

Reference : 

Healthline. Diakses pada 2022. Ibuprofen (Advil) Side Effects: What You Need to Know.

NHS. Diakses pada 2022. Side Effects of Ibuprofen.